Two Arm Survival - Interim Stopping

Futility Monitoring on a standard 2 arm randomized Phase II study. Specify Standard Design for two arms. Specify interim analysis in terms of accrual time, + additional follow. Calculate tests and HR1 rule at interim analysis. Conduct test at complete analysis.

For further details, view the Help Document.

User Input

Program Output

Select Parameters

Type Input
Event Based
Accrual Timing

Number of Simulations*

Total Sample Size*

Proportion in Standard Group

Hazard Rate, Std.

Null Hazard Ratio

Alternative Hazard Ratio

Years of Accrual

Years of Follow-up

Proportion of Events

Proportion of Accrual at Interim

Years of Follow-up at Interim

Alpha

Alpha at Interim Analysis

* If you encounter a "Server error: timeout reached" message, please try smaller values for this input. Simulations can also be performed locally using the R code located in the Help Document.

Fraction of Accrual at Interim Analysis

Years of Follow-up at Interim

Years of Accrual at Interim

Patients Accrued at Interim Analysis

Probability of Stopping - Test of H_A

Probability of Stopping - HR 1 Rule

Power with Interim - Test of H_A

Power with Interim - HR 1 Rule

Power with No Interim

Critical Interim HR - Test of H_A

Help Document